In 2000, Universal Pictures released The Skulls: The Secret Society, starring Joshua Jackson and Paul Walker, who played Yale veterans who had been chosen to be part of the secret society. After a murder cover-up, a member tries to defect from the group. Society, it seems, has strained relationships between members, cover-ups, lewd ways of life, and corrupt businesses. The film has two sequels: The Skulls II and The Skulls III.
Mr. Burns, one of the characters on the television series The Simpsons, is a supposed bonesman of the 1914 course.
The Good Shepherd (2007), a Robert De Niro film with Matt Damon and Angelina Jolie in the main roles, explains the life of Edward Wilson (inspired by James Jesus Angleton), a member of the Skull & Bones and a CIA agent.
The chapter Don’t Forget Chris from Family Guy, is about Chris Griffin joining Skull & Bones thanks to his maternal grandfather.